Vityl Antiox



Vityl Antiox is a unique antioxidant formula combining some of nature’s most powerful herbs and spices, along with other classic and novel antioxidant compounds. These ingredients have been specifically selected for their ability to maintain the function and integrity of both water-based and lipid-based body structures and compounds, including cell
membranes, LDL cholesterol, proteins, and enzymes. There are many factors involved in the production of free radicals
including chronic stress, environmental pollutants, smoking, excessive alcohol use, overconsumption of poor quality fats and processed foods, and exposure to ultraviolet rays from the sun; factors that contribute to cellular dysfunction and cell death which translates to premature aging and a wide array of chronic diseases.1 Vityl Antiox is a comprehensive formulation containing a vast array of nutrients known for their protective effects against oxidative stress and free radicals. Antioxidants are naturally-occurring molecules within cells, primarily derived from vitamins within plant-based foods that donate their own electrons to free radicals in order to protect healthy cells from being damaged by these unstable overcharged molecules. Bioflavonoids are part of the greater category of bioactive substances called polyphenols, which are a large group of naturally-occurring antioxidant compounds ubiquitously found in most fruits and vegetables. Dietary polyphenols have beneficial effects against a broad group of diseases, particularly those that are inflammatory in pathology.

Vitamin A (from mixed carotenoids): Carotenoids have potent antioxidative properties with the ability to neutralize free radicals and reactive oxygen species (ROS), such as peroxyl radicals, and molecular oxygen (O2).2 β-carotene, in combination with other lipophilic antioxidants such as vitamins C and E, was shown to have synergistic effects contributing to significantly greater scavenging and neutralizing of reactive nitrogen species and lipid peroxidation compared with single carotenoids alone.2 In an animal study, lipid peroxide levels were significantly reduced in groups that received 4,000 and 8,000 IU/kg of vitamin A and significantly higher levels of glutathione concentrations compared to controls.3

Vitamin C: Vitamin C is an essential water-soluble nutrient that is unable to be synthesized endogenously by humans, thus it must be supplied through the diet or supplementation.4,5 Its antioxidant function is a hallmark of this nutrient; it is a potent neutralizer of free radicals and helps to recycle vitamin E and glutathione.4 Vitamin C’s ability to readily donate electrons, thus protecting proteins, lipids, carbohydrates, and nucleic acids from oxidative damage, significantly contributes to its immune-modulating properties.

Grape Seed Extract (GSE) (Vitis vinifera): The GSE in this formula is standardized to contain 95% proanthocyanidins. Grape seed proanthocyanidins have been shown to possess anticancer, vasoprotective, antioxidant, and neuroprotective qualities.6 A combination of 36 different phenolic acids, flavonoids, and other antioxidative compounds was found and analyzed in grape seed extract, demonstrating that grape seeds have a much higher proanthocyanidin content compared to the skin and flesh, and thus, have the highest antioxidative power, with an oxygen radical absorbance capacity (ORAC) of 8.62 ± 0.73.7 An in vitro study showed that at lower concentrations GSE decreased oxidative stress, increased steroidogenesis, and improved progesterone and estradiol secretion without affecting cell proliferation in a human tumor granulosa cell line, improving the chance of follicular development and survival in female reproductive health.8

Curcumin & Resveratrol: The non-flavonoid polyphenol, curcumin, is lipophilic, making it a potent collector of peroxyl radicals, and can also regulate the activity of glutathione, superoxide dismutase (SOD), and catalase enzymes that are responsible for neutralizing ROS.9 Curcumin C3 Complex® is a unique composition of three bioactive curcuminoids: curcumin, bisdemethoxycurcumin, and dimethoxy curcumin, shown to be the strongest and most protective constituents of turmeric root. Resveratrol is easily absorbed, and has shown the ability to scavenge hydroxyl radicals, prevent DNA damage caused by ROS, and upregulate the activity of SOD, catalase, and glutathione peroxidase enzymes.9 Aside from its antioxidative capacity, resveratrol possesses neuroprotective, anti-aging, cytoprotective, antithrombotic, DNA protective, anticarcinogenic, and anti-inflammatory properties.9 In both animal and human models, resveratrol supplementation displayed antioxidative activity for hypertension and type II diabetes.9

Garlic (Allium sativum L.): Garlic contains a diverse combination of potent bioactive sulfur-containing compounds that have been shown to impart antioxidant, anti-inflammatory, antimicrobial, antifungal, immune-regulating, cardioprotective, anticarcinogenic, antidiabetic, neuroprotective, hepatoprotective, and renal protective properties.10 A review shows that the active phenols and saponins within garlic have cytoprotective effects against damage caused by peroxyl radicals, and upregulates several antioxidant enzyme expression such as nuclear factor erythrobia-2 related factor (Nrf2), which have been shown to protect human epithelial cells against ROS, and may inhibit pro-inflammatory cytokine levels such as TNF-α and interleukin-1β.10

Vitamin E Isomers (Tocotrienols): This formula includes a tocopherol-free form of vitamin E isomers, (as DeltaGold® delta and gamma tocotrienols), that have unique health benefits. Tocotrienol-rich fractions, are well suited to protect the lipids within the cell membranes of a variety of tissues from oxidative stress as they fit perfectly into the lipid bilayer, making them desirable for supporting many aspects of health.1 Tocotrienols have been shown to protect neurons through mechanisms involving not only their antioxidant properties but also through the activation of protective signaling molecules. Animal studies demonstrate that tocotrienols are more effective than tocopherols at protecting neurons from glutamate-induced cell death.11 With mitochondrial dysfunction and oxidative damage increasingly believed to be involved in the pathogenesis of Alzheimer’s disease and other forms of neurodegeneration, antioxidant tocotrienols may be beneficial additions to existing therapies. Tocotrienols, specifically the gamma and delta isomers, have exhibited significant anti-cancer activities demonstrated through multiple mechanisms: enhanced apoptosis, cell cycle arrest, reduced angiogenesis and inhibition of proliferation (both due to reduction in vascular endothelial growth factor and reduced blood supply), enhanced immune function (increased expression of interferon-gamma, IgA and IgG), reduced risk of initial cancer occurrence (possibly resulting from the antioxidant protection of DNA), and reduced inflammation (decrease in NF-κB, IL-1, IL-6, TNF-α, COX-2, 12-LOX), as well as protection of normal tissues from radiation injury by altering endothelial cell function.14-16

Quercetin, Rutin, & Ginkgo biloba: Quercetin is considered to be among the top plant-based polyphenolic compounds due to its powerful antioxidant properties and its ability to support a healthy inflammatory response. Moreover, this polyphenolic compound also demonstrates an ability to aid in the attenuation of lipid peroxidation, capillary permeability, and platelet aggregation.18 Rutin is a dietary flavonol antioxidant that offers protective effects against advanced glycation end-product (AGE) formation. AGEs are formed by the reaction between reducing sugars and proteins and are another group of substances that contribute directly to the initiation and advancement of age-related diseases such as Alzheimer’s disease, type 2 diabetes, and atherosclerosis.19 In a study of the effects of the combination of ascorbic acid and rutin on human keratinocytes and fibroblasts exposed to UVA and UVB radiation, there was an increase of antioxidant enzyme activity (superoxide dismutase, catalase, and thioredoxin reductase), showed complementary effects against UV-induced free radical damage, silenced UV-induced expression of NF-???????? and pro-apoptotic proteins, suggesting that these compounds have cytoprotective properties against skin damage.20 Ginkgo biloba leaves are a natural source of polyphenols and bioflavonoids; they are widely used for cognitive health and have also shown favorable effects for those with digestive conditions.21 Six weeks of Ginkgo biloba extract supplementation was shown to impart benefits in physically-active healthy men by increasing levels of brain-derived neurotrophic factor (BDNF), VO2 max and blood antioxidant capacity.22

Synergistic Blend of Herbs & Spices: Rosemary (Rosmarinus officinalis), sage (Salvia officinalis), and clove (Syzygium aromaticum) are some of nature’s most powerful herbs and spices. A review looking at the antimicrobial and antioxidant properties of R. officinalis L. explains rosemary’s abundance in isoprenoid quinones, which “act as chain terminators of free radicals, and as chelators of reactive oxygen species (ROS)”.23 The major phenolic diterpenes (carnosic acid and carnosol) are responsible for 90% of the antioxidative properties in rosemary; they inhibit lipid peroxidation, scavenge hydroxyl and peroxyl radicals, and reduce cytochrome c complexes via activation of the redox-dependent signaling pathways. Salvia officinalis possesses anti-inflammatory, anti-nociceptive, antimutagenic, hypoglycemic, and hypolipidemic effects, as well as antioxidative and antibacterial due to the presence of carnosic acid and carnosol in sage.24 S. officinalis contains high contents of glycosidic flavones that show good inhibitory capacity against xanthine oxidase activity.25 An animal study showed clove oil extract to enhance anti-inflammatory activity by significantly reducing myeloperoxidase activity in human neutrophils, thus reducing ROS and a variety of other inflammatory mediators (e.g., IL-1, IL-6, TNF-α) that promote damage at the site of inflammation.26 Allspice berry (Pimenta dioica) was shown to have one of the highest total phenolic content among 14 commonly used herbs and spices, and to be one of the most active neutralizers of free radicals; allspice extract was the most effective inhibitor of advanced glycation end-product formation.27 Sweet basil (Ocimum basilicum L.) extract significantly suppressed pro-inflammatory cytokine production and expression in an in vitro model and was shown to considerably scavenge free radicals using the DPPH and ABTS assays, which are tests to show the amounts of phenolics and radical scavenging activities.28

Lutein & Lycopene: The carotenoid lutein helps protect the retina from the free radical damage it undergoes constantly from exposure to UV rays.29 Lutein-rich foods and supplements can increase macular pigment density, which has been shown in research to be associated with a lower risk of age-related macular degeneration.29 Lycopene, a powerful antioxidant phytonutrient found in cooked tomatoes, and other fruits and vegetables such as watermelon, carrots, and red cabbage, has been shown to protect male sex organs from oxidative stress, which is a major cause of male infertility.30 In the first-ever RCT evaluating the impact of dietary lycopene treatment on male sperm quality, lycopene supplementation showed significant improvements in sperm motility and morphology by 40% compared to placebo-controls.31 A systematic review of cell culture and animal studies found that tomato and lycopene treatment can down-regulate androgen metabolism and signaling in prostate cancer.32

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