How Multi Sync-Biotic Works
To promote gut health and overall wellness, Multi Sync-Biotic contains 30 billion colony-forming units (CFU) of a potent seven-strain blend of beneficial probiotics per serving.
Lactobacillus acidophilus NCFM®
L. acidophilus NCFM®, which stands for the research laboratory it was first discovered at (“North Carolina Food Microbiology” lab), is a patented beneficial lactic acid bacteria strain often used to promote and support a healthy gut microbe balance, thus supporting the digestion of simple sugars and other tough-to-digest nutrients. 6
This strain has been shown in numerous clinical trials to help relieve the symptoms of GI discomfort, especially bloating, flatulence, and loose stool. 7,8,9 Several studies have also found that L. acidophilus NCFM® shortens colon transit time and may activate certain receptors that ease colon discomfort associated with constipation. 10,11,12
Bifidobacterium lactis Bi-07® & BL-04®
B. lactis is a bacterial species that readily resists bile salts and acidic conditions (meaning it is able to withstand the harsh digestive environment of the human gut). 13 Like Lactobacilli, Bifidobacteria aid in the digestion of lactose and are critical for producing B vitamins, which serve a myriad of vital roles in the body. 14
B. lactis Bi-07® and B. lactis BL-04® are two of the most promising probiotic strains for supporting healthy immune response. A recent well-designed study including 465 healthy adults compared the effects of two probiotic supplements on the risk of colds and respiratory infections, one containing B. lactis Bi-07® plus L. acidophilus NCFM® and one containing B. lactis BL-04®.
Throughout the trial period, adults receiving the B. lactis Bi-07® plus L. acidophilus NCFM® probiotic supplement had a significantly lower risk of contracting an upper respiratory tract infection (URTI) and those taking the B. lactis BL-04® probiotic supplement were even less likely to contract a URTI. 15
Another study in 37 elderly subjects showed similar results, with the researchers finding beneficial effects of B. lactis Bi-07® on immune responses of the participants. 16 Further research shows that these specific B. lactis strains can help balance a healthy gut flora. 17
Lactobacillus plantarum LP-115® & Lactobacillus salivarius LS-33®
L. plantarum LP-115® helps promote a healthy gastrointestinal tract environment and support mineral absorption.
A well-controlled study in 24 healthy women showed that L. plantarum LP-115® supplementation increased iron absorption by 80% when consumed with a meal containing high amounts of phytic acid (a compound that hinders iron absorption).18 L. plantarum LP-115® appears to expose iron molecules to the intestinal lining for an extended duration, thereby increasing intestinal absorption.
L. salivarius LS-33® works in a similar fashion as L. plantarum to aid digestion of both macronutrients and micronutrients. 19 In addition, this particular probiotic grows rapidly and helps “crowd out” the bad bacteria in the gut microbiome and periodontal tissues. 20
Streptococcus thermophilus ST-21™
S. thermophilus ST-21™ is an integral gram-positive bacterium in human flora and is particularly important for digesting lactose, oligosaccharides, and supporting immune function. 21 It also appears to work in conjunction with B. lactis to produce antibiotic-like chemicals, thereby supporting healthy bacteria. 22
Saccharomyces boulardii DBVPG®
Saccharomyces boulardii DBVPG® is a nonpathogenic yeast strain. A contemporary meta-analysis contends that Saccharomyces boulardii supports gastrointestinal integrity by promoting healthy inflammatory responses in the intestines and colon of humans. 23
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3. Evans, J. M., Morris, L. S., & Marchesi, J. R. (2013). The gut microbiome: the role of a virtual organ in the endocrinology of the host. Journal of Endocrinology, 218(3), R37-R47.
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7. Rousseaux C. et al., (2007), ‘Lactobacillus acidophilus modulates intestinal pain and induces opioid and cannabinoid receptors’. Nature Medicine, 13(1):35-7.
8. Ringel-Kulka T., et al., (2011). ‘Probiotic Bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 Versus Placebo for the Symptoms of Bloating in Patients with Functional Bowel Disorders. A Double-blind Study’. Journal of Clinical Gastroenterology, 45: 518-525.
9. Sanders M. E, and Klaenhammer, T. R., (2001). ‘Invited Review: The Scientific Basis of Lactobacillus acidophilus NCFM Functionality as a Probiotic’. Journal of Dairy Science Vol. 84(2):319-331.
10. Magro, D.O., et al., (2014). ‘Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation’. Nutrition Journal, 13:75.
11. Faber, S.M., (2000). ‘Treatment of abnormal gut flora improves symptoms in patients with irritable bowel syndrome’. American Journal of Gastroenterology, 95(9):2533.
12. Ringel-Kulka T., et al., (2014). ‘Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression in patients with functional abdominal pain – a randomised clinical study’. Aliment Pharmacological Therapy., 40(2):200-7. doi: 10.1111/apt.12800
13. Hyronimus, B., Le Marrec, C., Sassi, A. H., & Deschamps, A. (2000). Acid and bile tolerance of spore-forming lactic acid bacteria. International journal of food microbiology, 61(2), 193-197.
14. Karina Pokusaeva, Gerald F. Fitzgerald,Douwe van Sinderen (2011). Carbohydrate metabolism in Bifidobacteria. Genes Nutr.; 6(3): 285–306.
15. Cox et al., (2014). ‘Effects of probiotic supplementation over 5 months on routine haematology and clinical chemistry measures in healthy active adults’, Eur J Clin Nutr., 68(11):1255-7. doi: 10.1038/ejcn.2014.137. Epub 2014 Jul 23.
16. Maneerat S. et al., (2013). ‘Consumption of Bifidobacterium lactis Bi-07 by healthy elderly adults enhances phagocytic activity of monocytes and granulocytes’ J Nutr Sci.., 2(2):e44.
17. Engelbrektson, AL, et al (2009) ‘A randomized, double blind, controlled trial of probiotics to minimize the disruption of fecal microbiota in healthy subjects undergoing antibiotic therapy’. Journal of Medical Microbiology, 58:663-670
18. Bering S. et al., (2006), ‘A lactic acid-fermented oat gruel increases non-haem iron absorption from a phytate-rich meal in healthy women of childbearing age’. British Journal of Nutrition, 96:80-85.
19. Messaoudi, S., Manai, M., Kergourlay, G., Prévost, H., Connil, N., Chobert, J. M., & Dousset, X. (2013). Lactobacillus salivarius: bacteriocin and probiotic activity. Food microbiology, 36(2), 296-304.
20. Iwamoto, T., Suzuki, N., Tanabe, K., Takeshita, T., & Hirofuji, T. (2010). Effects of probiotic Lactobacillus salivarius WB21 on halitosis and oral health: an open-label pilot trial. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 110(2), 201-208.
21. Hols, P., Hancy, F., Fontaine, L., Grossiord, B., Prozzi, D., Leblond-Bourget, N., … & Guédon, E. (2005). New insights in the molecular biology and physiology of Streptococcus thermophilus revealed by comparative genomics. FEMS microbiology reviews, 29(3), 435-463.
22. Corrêa NB, Péret Filho LA, Penna FJ, Lima FM, Nicoli JR. A randomized formula controlled trial of Bifidobacterium lactis and Streptococcus thermophilus for prevention of antibiotic-associated diarrhea in infants. J Clin Gastroenterol. 2005 May-Jun;39(5):385-9.
23. McFarland, L. V. (2010). Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World journal of gastroenterology: WJG, 16(18), 2202.